Approaches to Support Student Learning in Introductory Programming Laboratory Classes

Objectives: This thesis will explore some innovative solutions to communication difficulties that exist in higher education teaching of introductory programming. Communication between a teacher and student is important, as it is the main opportunity where a student can ask a teacher questions about a particular problem they have, and a teacher can give feedback to direct them towards a solution. It is expected that through utilising technology in laboratory practical classes, communication between teachers and student can be improved. Methods: This thesis primarily explores the possibilities of using student compiler and method invocation data, collected during a practical class and sent directly to a teacher. This data maybe beneficial as a method of allowing teachers to see if a student requires help. This thesis utilises a variety of research methods including questionnaires, observations of classroom interactions and collection of data recorded from student and teachers interactions with the technology. The approaches are used during an investigation into the current approaches of laboratory practical teaching, before progressing onto investigations using the technology developed that accompanies this thesis. Results: The results identified that the majority of the students and teachers who used the technology felt that it improved their ability to communicate within laboratory practical classes. The teachers felt that they could use the data collected by the technology to view activity from the students and see a student’s progress. The teachers could interpret the data collected from the technology and students who needed help could be identified. Conclusions: This thesis has demonstrated that technology has the potential to improve communication in laboratory classes, and enable teachers to support students more effectively. However, the technology developed in this thesis, does not eliminate the requirement for a teacher to interact with a student face-to-face, but rather its role is to act as an indicator of students who may need assistance

Preclinical Evaluation of Bispecific Adaptor Molecule Controlled Folate Receptor CAR-T Cell Therapy With Special Focus on Pediatric Malignancies

Chimeric antigen receptor (CAR)-T cell therapy has transformed pediatric oncology by producing high remission rates and potent effects in CD19+ B-cell malignancies. This scenario is ideal as CD19 expression is homogeneous and human blood provides a favorable environment for CAR-T cells to thrive and destroy cancer cells (along with normal B cells). Yet, CAR-T cell therapies for solid tumors remain challenged by fewer tumor targets and poor CAR-T cell performances in a hostile tumor microenvironment. For acute myeloid leukemia and childhood solid tumors such as osteosarcoma, the primary treatment is systemic chemotherapy that often falls short of expectation especially for relapsed and refractory conditions. We aim to develop a CAR-T adaptor molecule (CAM)-based therapy that uses a bispecific small-molecule ligand EC17, fluorescein isothiocyanate (FITC) conjugated with folic acid, to redirect FITC-specific CAR-T cells against folate receptor (FR)-positive tumors. As previously confirmed in rodents as well as in human clinical studies, EC17 penetrates solid tumors within minutes and is retained due to high affinity for the FR, whereas unbound EC17 rapidly clears from the blood and from receptor-negative tissues. When combined with a rationally designed CAR construct, EC17 CAM was shown to trigger CAR-modified T cell activation and cytolytic activity with a low FR threshold against tumor targets. However, maximal cytolytic potential correlated with (i) functional FR levels (in a semi-log fashion), (ii) the amount of effector cells present, and (iii) tumors' natural sensitivity to T cell mediated killing. In tumor-bearing mice, administration of EC17 CAM was the key to drive CAR-T cell activation, proliferation, and persistence against FR+ pediatric hematologic and solid tumors. In our modeling systems, cytokine release syndrome (CRS) was induced under specific conditions, but the risk of severe CRS could be easily mitigated or prevented by applying intermittent dosing and/or dose-titration strategies for the EC17 CAM. Our approach offers the flexibility of antigen control, prevents T cell exhaustion, and provides additional safety mechanisms including rapid reversal of severe CRS with intravenous sodium fluorescein. In this paper, we summarize the translational aspects of our technology in support of clinical development

What Phase of the Interstellar Medium Correlates with the Star Formation Rate?

Nearby spiral galaxies show an extremely tight correlation between tracers of molecular hydrogen (H_2) in the interstellar medium (ISM) and tracers of recent star formation, but it is unclear whether this correlation is fundamental or accidental. In the galaxies that have been surveyed to date, H_2 resides predominantly in gravitationally bound clouds cooled by carbon monoxide (CO) molecules, but in galaxies of low metal content the correlations between bound clouds, CO, and H_2 break down, and it is unclear if the star formation rate will then correlate with H_2 or with some other quantity. Here we show that star formation will continue to follow H_2 independent of metallicity. This is not because H_2 is directly important for cooling, but instead because the transition from predominantly atomic hydrogen (HI) to H_2 occurs under the same conditions as a dramatic drop in gas temperature and Bonnor-Ebert mass that destabilizes clouds and initiates collapse. We use this model to compute how star formation rate will correlate with total gas mass, with mass of gas where the hydrogen is H_2, and with mass of gas where the carbon is CO in galaxies of varying metallicity, and show that preliminary observations match the trend we predict.Comment: 13 pages, 7 figures, emulateapj format, accepted to ApJ; minor revisions to discussion, and a minor error in figures 4 and 5 fixed. No other change

The s ---> d gamma decay in and beyond the Standard Model

The New Physics sensitivity of the s ---> d gamma transition and its accessibility through hadronic processes are thoroughly investigated. Firstly, the Standard Model predictions for the direct CP-violating observables in radiative K decays are systematically improved. Besides, the magnetic contribution to epsilon prime is estimated and found subleading, even in the presence of New Physics, and a new strategy to resolve its electroweak versus QCD penguin fraction is identified. Secondly, the signatures of a series of New Physics scenarios, characterized as model-independently as possible in terms of their underlying dynamics, are investigated by combining the information from all the FCNC transitions in the s ---> d sector.Comment: 54 pages, 14 eps figure

Absolute Zero : Delivering the UK's climate Change Commitment with Incremental Changes to Today's Technologies

We have to cut our greenhouse gas emissions to zero by 2050: that's what climate scientists tell us, it's what social protesters are asking for and it's now the law in the UK. But we aren't on track. For twenty years we've been trying to solve the problem with new or breakthrough technologies that supply energy and allow industry to keep growing, so we don't have to change our lifestyles. But although some exciting new technology options are being developed, it will take a long time to deploy them, and they won't be operating at scale within thirty years. Meanwhile, our cars are getting heavier, we're flying more each year and we heat our homes to higher temperatures. We all know that this makes no sense, but it's difficult to start discussing how we really want to address climate change while we keep hoping that new technologies will take the problem away. In response, this report starts from today's technologies: if we really want to reach zero emissions in thirty years time, what does that involve? Most of what we most enjoy - spending time together as families or communities, leisure, sport, creativity - can continue and grow unhindered. We need to switch to using electricity as our only form of energy and if we continue today's impressive rates of growth in non-emitting generation, we'll only have to cut our use of energy to 60% of today's levels. We can achieve this with incremental changes to the way we use energy: we can drive smaller cars and take the train when possible, use efficient electric heat-pumps to keep warm and buy buildings, vehicles and equipment that are better designed and last much longer. The two big challenges we face with an all electric future are flying and shipping. Although there are lots of new ideas about electric planes, they won’t be operating at commercial scales within 30 years, so zero emissions means that for some period, we'll all stop using aeroplanes. Shipping is more challenging: although there are a few military ships run by nuclear reactors, we currently don’t have any large electric merchant ships, but we depend strongly on shipping for imported food and goods. In addition, obeying the law of our Climate Change Act requires that we stop doing anything that causes emissions regardless of its energy source. This requires that we stop eating beef and lamb - ruminants who release methane as they digest grass - and already many people have started to switch to more vegetarian diets. However the most difficult problem is cement: making cement releases emissions regardless of how it’s powered, there are currently no alternative options available at scale, and we don’t know how to install new renewables or make new energy efficient buildings without it. We need to discuss these challenges as a society. Making progress on climate change requires that the three key groups of players - government, businesses and individuals - work together, rather than waiting for the other two to act first. But until we face up to the fact that breakthrough technologies won’t arrive fast enough, we can’t even begin having the right discussion. Committing to zero emissions creates tremendous opportunities: there will be huge growth in the use and conversion of electricity for travel, warmth and in industry; growth in new zero emissions diets; growth in materials production, manufacturing and construction compatible with zero emissions; growth in leisure and domestic travel; growth in businesses that help us to use energy efficiently and to conserve the value in materials. Bringing about this change, and exploring the opportunities it creates requires three things to happen together: as individuals we need to be part of the process, exploring the changes in lifestyle we prefer in order to make zero emission a reality. Protest is no longer enough - we must together discuss the way we want the solution to develop; the government needs to treat this as a delivery challenge - just like we did with the London Olympics, ontime and on-budget; the emitting businesses that must close cannot be allowed to delay action, but meanwhile the authors of this report are funded by the government to work across industry to support the transition to growth compatible with zero emissions. Breakthrough technologies will be important in the future but we cannot depend on them to reach our zero emissions target in 2050. Instead this report sets an agenda for a long-overdue public conversation across the whole of UK society about how we really want to achieve Absolute Zero within thirty years

Absolute Zero

We can’t wait for breakthrough technologies to deliver net-zero emissions by 2050. Instead, we can plan to respond to climate change using today’s technologies with incremental change. This will reveal many opportunities for growth but requires a public discussion about future lifestyles

Membrane fission by dynamin: what we know and what we need to know

Abstract The large GTPase dynamin is the first protein shown to catalyze membrane fission. Dynamin and its related proteins are essential to many cell functions, from endocytosis to organelle division and fusion, and it plays a critical role in many physiological functions such as synaptic transmission and muscle contraction. Research of the past three decades has focused on understanding how dynamin works. In this review, we present the basis for an emerging consensus on how dynamin functions. Three properties of dynamin are strongly supported by experimental data: first, dynamin oligomerizes into a helical polymer; second, dynamin oligomer constricts in the presence of GTP; and third, dynamin catalyzes membrane fission upon GTP hydrolysis. We present the two current models for fission, essentially diverging in how GTP energy is spent. We further discuss how future research might solve the remaining open questions presently under discussion

P25@CoAl layered double hydroxide heterojunction nanocomposites for CO2 photocatalytic reduction

Artificial photosynthesis driven by inorganic photocatalysts offers a promising route to renewable solar fuels, however efficient CO2 photoreduction remains a challenge. A family of hierarchical nanocomposites, comprising P25 nanoparticles encapsulated within microporous CoAl-layered double hydroxides (CoAl-LDHs) were prepared via a one-pot hydrothermal synthesis. Heterojunction formation between the visible light absorbing CoAl-LDH and UV light absorbing P25 semiconductors extends utilisation of the solar spectrum, while the solid basicity of the CoAl-LDH increases CO2 availability at photocatalytic surfaces. Matching of the semiconductor band structures and strong donor–acceptor coupling improves photoinduced charge carrier separation and transfer via the heterojunction. Hierarchical P25@CoAl-LDH nanocomposites exhibit good activity and selectivity (>90%) for aqueous CO2 photoreduction to CO, without a sacrificial hole acceptor. This represents a facile and cost-effective strategy for the design and development of LDH-based nanomaterials for efficient photocatalysis for renewable solar fuel production from particularly CO2 and aqueous water

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Compressed representation of a partially defined integer function over multiple arguments

In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one